Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

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teal horse blanket Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro.In addition to their known anticoagulants activity this potential inhibition could have an additional therapeutic effect on patients with COVID-19 disease.In this study we examined the binding of the Apixaban, Betrixaban and Rivaroxaban to the SARS-CoV-2 Mpro with the use of the MicroScale Thermophoresis technique.

Our results indicate marni shirt green that the experimentally measured binding affinity is weak and the therapeutic effect due to the SARS-CoV-2 Mpro inhibition is rather negligible.